Canadian Medical Guide > Chemicals and Drugs > Immunologic and Biological Factors > Immunologic Factors > Antibodies > Autoantibodies Terms and Definitions

Autoantibodies

Medical Definition:	Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.
Guide Notes:	do not confuse with ANTIBODIES, ANTI-IDIOTYPIC

Autoantibodies Categories.

	Antibodies, Antinuclear - Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
	Antibodies, Antiphospholipid - Autoantibodies directed against phospholipids. These antibodies are characteristically found in patients with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS; SYSTEMIC), ANTIPHOSPHOLIPID SYNDROME; related autoimmune diseases, some non-autoimmune diseases, and also in healthy individuals.
	Long-Acting Thyroid Stimulator - Thyroid stimulator, long-acting. An immunoglobulin G, often found in the blood of hyperthyroid individuals. It stimulates the thyroid for a longer duration than does thyrotoxin and may cause hyperthyroidism in newborns due to placental transmission.
	Rheumatoid Factor - Antibodies directed against antigenic determinants, i.e., Gm (gamma chain), in the Fc region of IMMUNOGLOBULIN G, found in the serum of about 80% of patients with classical or definite rheumatoid arthritis, but in only about 20% of patients with juvenile rheumatoid arthritis. Rheumatoid factors may be IMMUNOGLOBULIN M, IMMUNOGLOBULIN G, or IMMUNOGLOBULIN A antibodies, although other serological tests measure only IMMUNOGLOBULIN M. Rheumatoid factors also occur in other connective tissue diseases and infectious diseases. (From Dorland, 28th ed)

Autoantibodies Medical Definitions and Terms

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