Canadian Medical Guide > Chemicals and Drugs > Heterocyclic Compounds > Alkaloids > Indole Alkaloids Terms and Definitions

Indole Alkaloids

Medical Definition:	Group of alkaloids containing a benzylpyrrole group (derived from TRYPTOPHAN)
Guide Notes:	GEN or unspecified; prefer specifics
Previously Indexed:	Alkaloids (1966-2001),Indoles (1966-2001)

Indole Alkaloids Categories.

	Curare - Plant extracts from several species, including Strychnos toxifera, S. castelnaei, S. crevauxii, and Chondodendron tomentosum, that produce paralysis of skeletal muscle and are used adjunctively with general anesthesia. These extracts are toxic and must be used with the administration of artificial respiration.
	Staurosporine - An indolocarbazole that is a potent PROTEIN KINASE C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)
	Vinca Alkaloids - A group of indole-indoline dimers which are ALKALOIDS obtained from the VINCA genus of plants. They inhibit polymerization of TUBULIN into MICROTUBULES thus blocking spindle formation and arresting cells in METAPHASE. They are some of the most useful ANTINEOPLASTIC AGENTS.

Indole Alkaloids Medical Definitions and Terms

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