Canadian Medical Guide > Chemicals and Drugs > Heterocyclic Compounds > Heterocyclic Compounds, 3-Ring > Acridines > Aminoacridines Terms and Definitions




Aminoacridines

Medical Definition: Acridines which are substituted in any position by one or more amino groups or substituted amino groups.
Previously Indexed: Acridines (1966-1979)
Aminoacridines Categories.
Canadian Medical Guide Definition Acridine Orange - A cationic cytochemical stain specific for cell nuclei, especially DNA. It is used as a supravital stain and in fluorescence cytochemistry. It may cause mutations in microorganisms.
Canadian Medical Guide Definition Acriflavine - 3,6-Diamino-10-methylacridinium chloride mixt. with 3,6-acridinediamine. Fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication.
Canadian Medical Guide Definition Aminacrine - A highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA. It is also used as an intracellular pH indicator.
Canadian Medical Guide Definition Amsacrine - Aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects.
Canadian Medical Guide Definition Ethacridine - A topically applied anti-infective agent.
Canadian Medical Guide Definition Nitracrine - Acridine antineoplastic agent used in mammary and ovarian tumors. It inhibits RNA synthesis.
Canadian Medical Guide Definition Proflavine - 3,6-Diaminoacridine. Topical antiseptic used mainly in wound dressings.
Canadian Medical Guide Definition Quinacrine - An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
Canadian Medical Guide Definition Tacrine - A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.

Aminoacridines Medical Definitions and Terms

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