Canadian Medical Guide

Canadian Medical Guide > Chemicals and Drugs > Amino Acids, Peptides, and Proteins > Proteins > Cell Cycle Proteins Terms and Definitions

Cell Cycle Proteins

Medical Definition:	Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and phosphoprotein phosphatases (PHOSPHOPROTEIN PHOSPHATASE) as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.
Previously Indexed:	Cell Cycle (1978-1994),Cell Division (1966-1994)

Cell Cycle Proteins Categories.

p14ARF Protein - A gene product of the p16 tumor suppressor gene (GENES, P16). It antagonizes the function of mdm2 protein (which regulates p53 by targeting it for degradation). p14ARF is produced from the beta mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced alpha transcript, is PROTEIN P16. Both p16 gene products have tumor suppressor functions.

Protein p16 - A gene product of the p16 tumor suppressor gene (GENES, P16). It is also called INK4 or INK4A because it is the prototype member the INK4 family - inhibitors of cyclin-dependent kinase CDK4. This protein is produced from the alpha mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced beta transcript, is P14ARF PROTEIN. Both p16 gene products have tumor suppressor functions.