Multigene Family
| Medical Definition: |
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed) |
| Also Called: |
Genes, Reiterated,Gene Clusters |
| Previously Indexed: |
Genes (1966-1970),Genes, Bacterial (1982-1986),Genes, Structural (1971-1986),Genes, Viral (1978-1986) |
Multigene Family Categories.
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Genes, rRNA - Genes, found in both prokaryotes and eukaryotes, which are transcribed to produce the RNA which is incorporated into RIBOSOMES. Prokaryotic rRNA genes are usually found in OPERONS dispersed throughout the GENOME, whereas eukaryotic rRNA genes are clustered, multicistronic transcriptional units. |
Multigene Family Medical Definitions and Terms
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