Genes, T-Cell Receptor
| Medical Definition: |
DNA sequences, in cells of the T-lymphocyte lineage, that code for T-cell receptors. The TcR genes are formed by somatic rearrangement (see GENE REARRANGEMENT, T-LYMPHOCYTE and its children) of germline gene segments, and resemble Ig genes in their mechanisms of diversity generation and expression. |
| Guide Notes: |
GEN or unspecified; prefer specifics; DF: note short X ref |
Genes, T-Cell Receptor Categories.
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Genes, T-Cell Receptor alpha - DNA sequences encoding the alpha chain of the T-cell receptor. The genomic organization of the TcR alpha genes is essentially the same in all species and is similar to the organization of Ig genes. |
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Genes, T-Cell Receptor beta - DNA sequences encoding the beta chain of the T-cell receptor. The genomic organization of the TcR beta genes is essentially the same in all species and is similar to the organization of Ig genes. |
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Genes, T-Cell Receptor delta - DNA sequences encoding the delta chain of the T-cell receptor. The delta-chain locus is located entirely within the alpha-chain locus. |
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Genes, T-Cell Receptor gamma - DNA sequences encoding the gamma chain of the T-cell receptor. The human gamma-chain locus is organized similarly to the TcR beta-chain locus. |
Genes, T-Cell Receptor Medical Definitions and Terms
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