Gene Silencing
| Medical Definition: |
Interruption or suppression of the expression of a gene at transcriptional or translational levels. |
| Previously Indexed: |
Gene Expression Regulation (1981-1999) |
Gene Silencing Categories.
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RNA Interference - A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX (RISC). DNA METHYLATION may also be triggered during this process. |
Gene Silencing Medical Definitions and Terms
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