Binding Sites
| Medical Definition: |
The reactive parts of a macromolecule that directly participate in its specific combination with another molecule. |
| Guide Notes: |
NIM; note category; restrict to site of binding: do not use as substitute for chem or metab mechanism of binding; do not coord with RECEPTORS terms unless the site of binding is particularly discussed |
| Also Called: |
Active Site |
| Previously Indexed: |
Antigen-Antibody Reactions (1966-1967),Enzymes (1966-1967) |
Binding Sites Categories.
 |
Allosteric Site - A site on an enzyme which upon binding of a modulator, causes the protein to undergo a conformational change that may alter the catalytic or binding properties of the enzyme. |
|
Bay Region (Chemistry) - An indentation of three fused benzene rings. A common bay region is the site on BENZO(A)PYRENE, an indirect carcinogen that is metabolically activated by the P-450 system at the 7,8-double bond, leading to a 7,8-oxide, which is rapidly converted to a 7,8-dihydrodiol and later epoxidated near the bay region at the 9,10-double bond. The resulting product, a diol-epoxide is a poor substrate for epoxide hydratase and is released from the mitochondria into the cell as a highly reactive electrophil, becoming an 'ultimate' carcinogen, as it reacts with negative charges in DNA. (From Segen, Dictionary of Modern Medicine, 1992) |
|
Binding, Competitive |
Binding Sites Medical Definitions and Terms
|
|
|
 |
 |
 CANADIAN
MEDICAL GUIDE
|
| Thank you for visiting
Canadian Medical Guide .com | | | | | |
|
|
 |
   |
 |
Canadian Medical Guide Catagories
| | |
